González-Fernández R A, Altieri P I, Díaz L M, Rodríguez P J, Fernández J, Miranda J G, Báez J, Cantellops D, Lugo J E
Department of Medicine, San Juan City Hospital, Puerto Rico University School of Medicine, Río Piedras.
Am J Hypertens. 1992 Jul;5(7):480-3. doi: 10.1093/ajh/5.7.480.
Ten hypertensive patients with symptoms of heart failure and normal systolic function but with diastolic dysfunction were treated with 10 mg enalapril twice a day for 9 +/- 3 months to evaluate the effects of this agent alone on heart failure induced by diastolic dysfunction. After therapy, all patients improved and echocardiographic parameters of diastolic dysfunction became normalized. It is concluded that enalapril appears to be useful in the treatment of heart failure in hypertensive patients with normal systolic function and diastolic dysfunction.
10例有心力衰竭症状、收缩功能正常但存在舒张功能障碍的高血压患者，每天服用10毫克依那普利，一日两次，持续9±3个月，以评估该药物单独使用对舒张功能障碍所致心力衰竭的疗效。治疗后，所有患者病情均有改善，舒张功能障碍的超声心动图参数恢复正常。结论是，依那普利似乎对收缩功能正常但存在舒张功能障碍的高血压心力衰竭患者的治疗有效。
