Chandra Jyotsna, Zhou Guangyin, Ghannoum Mahmoud A
Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106-5028, USA.
Curr Drug Targets. 2005 Dec;6(8):887-94. doi: 10.2174/138945005774912762.
Device-related infections in most nosocomial diseases can be traced to the formation of biofilms (microbial communities encased within a polysaccharide-rich extracellular matrix) by pathogens on surfaces of these devices. Candida species are the most common causative agents of these infections, and biofilms formed by these fungal organisms are associated with drastically enhanced resistance against most antimicrobial agents. This enhanced resistance contributes to the persistence of this fungus despite antifungal therapy. Recent studies showed that Candida biofilms exhibit antifungal resistance against most antifungal agents with the exception of echinocandins and lipid formulations of AMB. This review discusses methods used to evaluate biofilm resistance and provide information on susceptibility pattern of candidal biofilm as well as studies investigating the mechanisms underlying biofilm resistance.
在大多数医院感染性疾病中，与器械相关的感染可追溯到病原体在这些器械表面形成生物膜（包裹在富含多糖的细胞外基质中的微生物群落）。念珠菌属是这些感染最常见的病原体，这些真菌形成的生物膜与对大多数抗菌剂的耐药性大幅增强有关。尽管进行了抗真菌治疗，但这种增强的耐药性导致了这种真菌的持续存在。最近的研究表明，除棘白菌素和两性霉素B脂质制剂外，念珠菌生物膜对大多数抗真菌剂均表现出抗真菌耐药性。本文综述了用于评估生物膜耐药性的方法，提供念珠菌生物膜药敏模式的相关信息，以及探讨生物膜耐药性潜在机制的研究。
