Teodoro Guilherme R, Ellepola Kassapa, Seneviratne Chaminda J, Koga-Ito Cristiane Y
Oral Biopathology Graduate Program, São José dos Campos Institute of Science and Technology, Universidade Estadual Paulista São José dos Campos, Brazil.
Oral Sciences, Faculty of Dentistry, National University of Singapore Singapore, Singapore.
Front Microbiol. 2015 Dec 21;6:1420. doi: 10.3389/fmicb.2015.01420. eCollection 2015.
There has been a sharp rise in the occurrence of Candida infections and associated mortality over the last few years, due to the growing body of immunocompromised population. Limited number of currently available antifungal agents, undesirable side effects and toxicity, as well as emergence of resistant strains pose a considerable clinical challenge for the treatment of candidiasis. Therefore, molecules that derived from natural sources exhibiting considerable antifungal properties are a promising source for the development of novel anti-candidal therapy. Phenolic compounds isolated from natural sources possess antifungal properties of interest. Particularly, phenolic acids have shown promising in vitro and in vivo activity against Candida species. However, studies on their mechanism of action alone or in synergism with known antifungals are still scarce. This review attempts to discuss the potential use, proposed mechanisms of action and limitations of the phenolic acids in anti-candidal therapy.
在过去几年中，由于免疫功能低下人群数量不断增加，念珠菌感染的发生率及其相关死亡率急剧上升。目前可用的抗真菌药物数量有限、存在不良副作用和毒性，以及耐药菌株的出现，对念珠菌病的治疗构成了相当大的临床挑战。因此，源自天然来源且具有相当抗真菌特性的分子是开发新型抗念珠菌疗法的一个有前景的来源。从天然来源分离出的酚类化合物具有令人感兴趣的抗真菌特性。特别是，酚酸已显示出对念珠菌属有良好的体外和体内活性。然而，关于它们单独的作用机制或与已知抗真菌药物协同作用的研究仍然很少。本综述试图讨论酚酸在抗念珠菌治疗中的潜在用途、提出的作用机制和局限性。
