目前使用的抗真菌药物：抗菌谱、作用方式及耐药性产生
Currently used antimycotics: spectrum, mode of action and resistance occurrence.
作者信息
Francois Isabelle E J A, Aerts An M, Cammue Bruno P A, Thevissen Karin
机构信息
Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, Kasteelpark Arenberg 20, B-3001 Heverlee, Belgium.
出版信息
Curr Drug Targets. 2005 Dec;6(8):895-907. doi: 10.2174/138945005774912744.
The increasing incidence of fungal infections combined with the emerging problem of antifungal drug resistance have prompted investigations of the mode of action of the currently used antifungal therapeutics (antimycotics). The routinely used antimycotics can be grouped into six different classes based on their mode of action. In this review, the mode of action and antifungal spectrum of these classes are discussed, together with possible resistance development against them.
真菌感染发病率的不断上升以及抗真菌药物耐药性这一新兴问题，促使人们对目前使用的抗真菌治疗药物（抗真菌剂）的作用方式展开研究。常规使用的抗真菌剂可根据其作用方式分为六大不同类别。在本综述中，将讨论这些类别的作用方式、抗真菌谱以及针对它们可能出现的耐药性发展情况。
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