Wilting J, Hawighorst T, Hecht M, Christ B, Papoutsi M
Children's Hospital, Pediatrics I, University of Goettingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany.
Curr Med Chem. 2005;12(26):3043-53. doi: 10.2174/092986705774933407.
In human solid cancer, the lymph node status is the most important prognostic indicator for the clinical outcome of patients. Follow-up data has shown that about 80% of metastasis follows an orderly pattern of progression via the lymphatic network while about 20% systemic metastasis occurs, bypassing the lymphatic system. Over the past few years, advances have been made in understanding the cellular and molecular aspects of physiological lymphangiogenesis and tumour-induced lymphangiogenesis, and the majority of studies point out to a positive correlation between tumour-induced lymphangiogenesis and lymphatic metastasis. However, the impact of intra- and peritumoural lymphatics on the tumour biology and the first steps of lymphatic metastasis, i.e. the invasion of tumour cells into the lymphatic vessels, are not well understood. We will give an outline of i. the physiological process of lymphangiogenesis, ii. tumour-induced lymphangiogenesis and lymphatic metastasis, iii. lymphatic invasion and the common pathways of tumour-lymphangiogenesis and lymphatic invasion. The growing interest in this topic has brought up a number of new molecular players in the field, which may provide the basis for a rational therapy against the process of lymphatic dissemination of tumour cells.
在人类实体癌中，淋巴结状态是患者临床预后最重要的预后指标。随访数据显示，约80%的转移遵循通过淋巴网络有序进展的模式，而约20%发生全身转移，绕过淋巴系统。在过去几年中，在理解生理性淋巴管生成和肿瘤诱导的淋巴管生成的细胞和分子方面取得了进展，并且大多数研究指出肿瘤诱导的淋巴管生成与淋巴转移之间存在正相关。然而，肿瘤内和肿瘤周围淋巴管对肿瘤生物学的影响以及淋巴转移的第一步，即肿瘤细胞侵入淋巴管，尚未得到充分了解。我们将概述：i. 淋巴管生成的生理过程；ii. 肿瘤诱导的淋巴管生成和淋巴转移；iii. 淋巴浸润以及肿瘤-淋巴管生成和淋巴浸润的共同途径。对该主题日益增长的兴趣在该领域带来了一些新的分子参与者，这可能为针对肿瘤细胞淋巴扩散过程的合理治疗提供基础。
