Siriwardena B S M S, Kudo Y, Ogawa I, Udagama M N G P K, Tilakaratne W M, Takata T
Department of Oral and Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
J Clin Pathol. 2008 Jan;61(1):103-8. doi: 10.1136/jcp.2007.047662. Epub 2007 Mar 9.
Nodal metastasis is a major prognostic indicator for oral squamous cell carcinoma (OSCC) progression. Recently, it has been revealed that lymphangiogenic growth factor VEGF-C and its receptor Flt-4 play an important role for invasion and metastasis in cancer cells.
To examine VEGF-C expression and its correlation with lymphatic status, including the number of lymph vessels and lymphatic invasion, tumour invasion and metastasis in OSCC.
Intratumoural and peritumoural lymphatic vessels were examined using D2-40 in 54 OSCC cases and correlated with VEGF-C expression and clinicopathological findings. The histological pattern of invasion and pathological findings were compared.
High expression of VEGF-C was frequently observed in OSCC and was associated with increased number of lymph vessels and lymphatic invasion. VEGF-C was well correlated with invasion pattern and metastasis.
Results suggest that VEGF-C may play an important role for lymphangiogenesis and invasion in the metastatic process and can be a strong predicting factor for metastasis of OSCC.
淋巴结转移是口腔鳞状细胞癌（OSCC）进展的主要预后指标。最近，有研究表明淋巴管生成生长因子VEGF - C及其受体Flt - 4在癌细胞的侵袭和转移中起重要作用。
检测OSCC中VEGF - C的表达及其与淋巴状态的相关性，包括淋巴管数量、淋巴浸润、肿瘤侵袭和转移情况。
采用D2 - 40对54例OSCC病例的肿瘤内和肿瘤周围淋巴管进行检测，并与VEGF - C表达及临床病理结果进行相关性分析。比较侵袭的组织学模式和病理结果。
在OSCC中经常观察到VEGF - C的高表达，且与淋巴管数量增加和淋巴浸润相关。VEGF - C与侵袭模式和转移密切相关。
结果表明VEGF - C可能在转移过程中的淋巴管生成和侵袭中起重要作用，并且可能是OSCC转移的一个强有力的预测因素。
