Palkó Márta, Kiss Loránd, Fülöp Ferenc
Institute of Pharmaceutical Chemistry, University of Szeged, H-6701 Szeged, PO Box 121, Hungary.
Curr Med Chem. 2005;12(26):3063-83. doi: 10.2174/092986705774933443.
This review is intended to give a short summary of the developments in the field of natural and synthetic alicyclic and heterocyclic hydroxylated beta-amino acids and to focus on the main strategies that have been reported for their synthesis. Given the medicinal and biological significance of the hydroxylated beta-amino acids, an increasing volume of research is currently being directed toward regio-, stereo- and enantioselective access to this class of compounds.
本综述旨在简要总结天然及合成的脂环族和杂环族羟基化β-氨基酸领域的发展情况,并重点关注已报道的其合成的主要策略。鉴于羟基化β-氨基酸的药用和生物学意义,目前越来越多的研究致力于区域选择性、立体选择性和对映选择性地合成这类化合物。