环状β-（酰基氨基）丙烯酸酯的四取代烯烃的对映选择性氢化反应。
Enantioselective hydrogenation of tetrasubstituted olefins of cyclic beta-(acylamino)acrylates.
作者信息
Tang Wenjun, Wu Shulin, Zhang Xumu
机构信息
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
出版信息
J Am Chem Soc. 2003 Aug 13;125(32):9570-1. doi: 10.1021/ja035777h.
PMID:12904006
Abstract
Hydrogenation of a series of cyclic beta-(acylamino)acrylates with tetrasubstituted olefins has been accomplished successfully with the use of Ru catalysts with chiral biaryl ligands such as C3-TunaPhos, and up to over 99% ee's have been achieved. This methodology provides an efficient catalytic method for the synthesis of both cis and trans chiral cyclic beta-amino acid derivatives.
摘要
使用带有手性联芳基配体（如C3-金枪鱼磷）的钌催化剂，已成功实现了一系列带有四取代烯烃的环状β-（酰基氨基）丙烯酸酯的氢化反应，对映体过量值（ee值）高达99%以上。该方法为顺式和反式手性环状β-氨基酸衍生物的合成提供了一种高效的催化方法。
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