Tang Wenjun, Wu Shulin, Zhang Xumu
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
J Am Chem Soc. 2003 Aug 13;125(32):9570-1. doi: 10.1021/ja035777h.
Hydrogenation of a series of cyclic beta-(acylamino)acrylates with tetrasubstituted olefins has been accomplished successfully with the use of Ru catalysts with chiral biaryl ligands such as C3-TunaPhos, and up to over 99% ee's have been achieved. This methodology provides an efficient catalytic method for the synthesis of both cis and trans chiral cyclic beta-amino acid derivatives.
使用带有手性联芳基配体（如C3-金枪鱼磷）的钌催化剂，已成功实现了一系列带有四取代烯烃的环状β-（酰基氨基）丙烯酸酯的氢化反应，对映体过量值（ee值）高达99%以上。该方法为顺式和反式手性环状β-氨基酸衍生物的合成提供了一种高效的催化方法。
