异氟烷麻醉期间的躯体运动和食管动力

Somatic movement and oesophageal motility during isoflurane anaesthesia.

作者信息

Mather C, Raftery S, Prys-Roberts C

机构信息

Sir Humphrey Davy Department of Anaesthesia, Bristol Royal Infirmary.

出版信息

Br J Anaesth. 1992 Jul;69(1):40-4. doi: 10.1093/bja/69.1.40.

DOI:10.1093/bja/69.1.40

PMID:1637602

Abstract

The quantal responses for somatic movement, and spontaneous and provoked lower oesophageal contractions (motility) were noted at the time of incision in 72 patients aged 40-65 yr, receiving varying concentrations of isoflurane. Probit analysis of the alveolar concentration of isoflurane required to prevent somatic movement revealed an MAC or EC50 (95% confidence limits) of 1.00 (0.82-1.17)% and EC95 of 2.16 (1.69-3.89)%. The EC50 of isoflurane to suppress spontaneous lower oesophageal contractions was 1.27 (1.12-1.43)%, and the EC95 2.13 (1.78-3.22)%. The EC50 for provoked lower oesophageal contractions was 1.31 (0.93-3.48)% and the EC95 was 6.18% (unable to compute confidence limits).

摘要

在72名年龄在40至65岁、接受不同浓度异氟烷的患者手术切开时，记录了躯体运动的剂量反应以及自发性和诱发性食管下括约肌收缩（运动功能）。对防止躯体运动所需的异氟烷肺泡浓度进行概率分析显示，最小肺泡浓度（MAC）或半数有效浓度（EC50，95%置信区间）为1.00（0.82 - 1.17）%，95%有效浓度（EC95）为2.16（1.69 - 3.89）%。异氟烷抑制自发性食管下括约肌收缩的EC50为1.27（1.12 - 1.43）%，EC95为2.13（1.78 - 3.22）%。诱发性食管下括约肌收缩的EC50为1.31（0.93 - 3.48）%，EC95为6.18%（无法计算置信区间）。