Canario Adelino V M, Rotllant Josep, Fuentes Juan, Guerreiro Pedro M, Rita Teodósio H, Power Deborah M, Clark Melody S
Centro de Ciências do Mar do Algarve, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal.
FEBS Lett. 2006 Jan 9;580(1):291-9. doi: 10.1016/j.febslet.2005.12.023. Epub 2005 Dec 19.
We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene.
