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本文引用的文献

1
EVALUATION OF THE TRYPAN BLUE TECHNIQUE FOR DETERMINATION OF CELL VIABILITY.用于测定细胞活力的台盼蓝技术评估
Transplantation. 1964 Nov;2:685-94. doi: 10.1097/00007890-196411000-00001.
2
Cellular pharmacokinetics of aclacinomycin A in cultured L1210 cells. Comparison with daunorubicin and doxorubicin.阿克拉霉素A在培养的L1210细胞中的细胞药代动力学。与柔红霉素和多柔比星的比较。
Cancer Chemother Pharmacol. 1982;8(2):243-9. doi: 10.1007/BF00255491.
3
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.用于细胞生长和存活的快速比色测定法：应用于增殖和细胞毒性测定。
J Immunol Methods. 1983 Dec 16;65(1-2):55-63. doi: 10.1016/0022-1759(83)90303-4.
4
Extracorporeally induced destruction of kidney stones by shock waves.体外冲击波诱导肾结石破坏
Lancet. 1980 Dec 13;2(8207):1265-8. doi: 10.1016/s0140-6736(80)92335-1.
5
Fragmentation of gallstones by extracorporeal shock waves.体外冲击波碎石治疗胆结石
N Engl J Med. 1986 Mar 27;314(13):818-22. doi: 10.1056/NEJM198603273141304.
6
Multiple mechanisms of resistance to cis-diamminedichloroplatinum(II) in murine leukemia L1210 cells.小鼠白血病L1210细胞对顺二氯二氨铂（II）的多种耐药机制。
Cancer Res. 1987 Apr 15;47(8):2056-61.
7
Histopathologic and ultrastructural correlates of tumor growth suppression by high energy shock waves.高能冲击波抑制肿瘤生长的组织病理学和超微结构相关性
J Urol. 1987 Feb;137(2):338-41. doi: 10.1016/s0022-5347(17)44018-3.
8
Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.基于四氮唑的半自动比色法评估：化学敏感性测试评估
Cancer Res. 1987 Feb 15;47(4):936-42.
9
High energy shock waves suppress tumor growth in vitro and in vivo.
J Urol. 1986 Mar;135(3):626-8. doi: 10.1016/s0022-5347(17)45764-8.
10
A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity.一项基于四唑盐染料（MTT）的细胞生长和化学敏感性检测中某些变量的研究。
Br J Cancer. 1987 Sep;56(3):279-85. doi: 10.1038/bjc.1987.190.

体外冲击波与细胞毒性药物的相互作用。

In vitro interaction of lithotripter shock waves and cytotoxic drugs.

作者信息

Gambihler S, Delius M

机构信息

Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Federal Republic of Germany.

出版信息

Br J Cancer. 1992 Jul;66(1):69-73. doi: 10.1038/bjc.1992.218.

DOI:10.1038/bjc.1992.218
PMID:1637679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1977919/
Abstract

The effect of a combination of lithotripter shock waves and cytotoxic drugs was examined in vitro. L1210 cells in suspension were exposed to shock waves during incubation with cislatin, doxorubicin, daunorubicin, THP-doxorubicin, or aclacinomycin. Proliferation was determined using the 3-4,5 dimethylthiazol-2,5 diphenyl tetrazolium bromide assay. Dose enhancement ratios were calculated for each drug in order to determine the effect of the additional exposure to shock waves. In addition, partition coefficients and IC50s of the drugs were determined. It was found, that the dose enhancement ratios increased for the drugs with decreasing cytotoxicity. The effect of all five drugs was enhanced by shock waves to a higher degree at 7 min incubation as compared to 50 min incubation. The effect of cisplatin was most significantly enhanced, with a dose enhancement ratio of 6.7 at 7 min incubation. The enhancement increased with the operating voltage used for generating the shock waves, and was only present when cells were exposed to shock waves during the incubation with the drug. An increase in cellular membrane permeability is proposed as the mechanism of interaction between shock waves and drugs.

摘要

在体外研究了碎石机冲击波与细胞毒性药物联合使用的效果。将悬浮状态的L1210细胞在与顺铂、阿霉素、柔红霉素、吡柔比星或阿克拉霉素孵育期间暴露于冲击波。使用3-(4,5-二甲基噻唑-2)-2,5-二苯基四氮唑溴盐法测定细胞增殖。计算每种药物的剂量增强率，以确定额外暴露于冲击波的效果。此外，还测定了药物的分配系数和半数抑制浓度（IC50）。结果发现，细胞毒性降低的药物其剂量增强率增加。与孵育50分钟相比，在孵育7分钟时，冲击波对所有五种药物的作用增强程度更高。顺铂的作用增强最为显著，在孵育7分钟时剂量增强率为6.7。增强作用随用于产生冲击波的操作电压增加而增加，且仅在细胞与药物孵育期间暴露于冲击波时才出现。有人提出细胞膜通透性增加是冲击波与药物相互作用的机制。