窄谱中波紫外线（TL-01）单药治疗、阿维A（re-TL-01）及阿维A-补骨脂素加长波紫外线（re-PUVA）治疗银屑病患者的疗效及复发率比较
A comparison of the efficacy and relapse rates of narrowband UVB (TL-01) monotherapy vs. etretinate (re-TL-01) vs. etretinate-PUVA (re-PUVA) in the treatment of psoriasis patients.
作者信息
Green C, Lakshmipathi T, Johnson B E, Ferguson J
机构信息
Department of Dermatology, Ninewells Hospital and Medical School, Dundee, Scotland, U.K.
出版信息
Br J Dermatol. 1992 Jul;127(1):5-9. doi: 10.1111/j.1365-2133.1992.tb14815.x.
Forty-five patients with extensive chronic plaque or guttate psoriasis were treated with either narrowband (TL-01) phototherapy, etretinate TL-01 combination therapy (re-TL-01) or etretinate and PUVA (re-PUVA) (15 patients in each group). Re-PUVA was the most effective therapy with 100% satisfactory clearance rate. TL-01 monotherapy had an 80% success rate; the relapse rate compared favourably with re-PUVA (50% in remission after 6 months). In the etretinate-TL-01 group, there was a 93% success rate and a one-third reduction in the total irradiation dose (8.0 J/cm2 vs. 12.7 J/cm2) but the relapse rate was higher, only 33% remaining in remission after 6 months.
45例广泛慢性斑块状或点滴状银屑病患者分别接受窄谱（TL-01）光疗、阿维A酯与TL-01联合治疗（阿维A酯-TL-01）或阿维A酯与补骨脂素加长波紫外线（PUVA）联合治疗（阿维A酯-PUVA）（每组15例）。阿维A酯-PUVA是最有效的治疗方法，清除率达100%，令人满意。TL-01单一疗法成功率为80%；复发率与阿维A酯-PUVA相比更有利（6个月缓解期为50%）。在阿维A酯-TL-01组，成功率为93%，总照射剂量降低了三分之一（8.0 J/cm²对12.7 J/cm²），但复发率更高，6个月后仅33%仍处于缓解期。
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