夹子装载器与复制起始

Clamp loaders and replication initiation.

作者信息

O'Donnell Mike, Kuriyan John

机构信息

The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10021, USA.

出版信息

Curr Opin Struct Biol. 2006 Feb;16(1):35-41. doi: 10.1016/j.sbi.2005.12.004. Epub 2006 Jan 11.

DOI:10.1016/j.sbi.2005.12.004

PMID:16377178

Abstract

Clamp loaders are ATP-driven multiprotein machines that couple ATP hydrolysis to the opening and closing of a circular protein ring around DNA. This ring-shaped clamp slides along DNA, and interacts with numerous proteins involved in DNA replication, DNA repair and cell cycle control. Recently determined structures of clamp loader complexes from prokaryotic and eukaryotic sources have revealed exciting new details of how these complex AAA+ machines perform this essential clamp loading function.

摘要

钳夹加载器是由ATP驱动的多蛋白机器，它将ATP水解与围绕DNA的环状蛋白环的打开和关闭相偶联。这个环形钳夹沿着DNA滑动，并与参与DNA复制、DNA修复和细胞周期控制的众多蛋白质相互作用。最近从原核生物和真核生物来源确定的钳夹加载器复合物的结构揭示了这些复杂的AAA+机器如何执行这一基本钳夹加载功能的令人兴奋的新细节。