Alavanja Michael C R, Bonner Matthew R
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA.
Cancer Invest. 2005;23(8):700-11. doi: 10.1080/07357900500360008.
The potential for human carcinogenicity of almost all pesticides currently on the market has been poorly evaluated and is inadequately understood. Generating mechanistic data in both animal studies and epidemiology will play an increasingly important role in the future. Improved exposure assessment, in large prospective studies that generate reliable exposure-response data that focus on individual pesticide exposures are needed. One of the greatest opportunities to make more rapid progress will be to foster more multi-disciplinary collaborations between toxicologists and epidemiologists. Collaborations on molecular epidemiology investigations offers such opportunities to both toxicologists and epidemiologists that were not possible even a decade ago.
目前市场上几乎所有农药对人类的致癌潜力都未得到充分评估，人们对此也了解不足。在动物研究和流行病学研究中生成机制数据在未来将发挥越来越重要的作用。在大规模前瞻性研究中改进暴露评估，这些研究要能生成聚焦于个体农药暴露的可靠暴露-反应数据。取得更快进展的最大机会之一将是促进毒理学家和流行病学家之间更多的多学科合作。分子流行病学调查方面的合作给毒理学家和流行病学家都带来了甚至在十年前都不可能有的机会。
