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抗生素浸渍聚甲基丙烯酸甲酯髋关节间隔物的抗生素释放及细菌生长抑制的体内和体外研究

In vivo and in vitro studies of antibiotic release from and bacterial growth inhibition by antibiotic-impregnated polymethylmethacrylate hip spacers.

作者信息

Kelm Jens, Regitz Thilo, Schmitt Eduard, Jung Werner, Anagnostakos Konstantinos

机构信息

Klinik für Orthopädie und Orthopädische Chirurgie, Homburg/Saar, Germany.

出版信息

Antimicrob Agents Chemother. 2006 Jan;50(1):332-5. doi: 10.1128/AAC.50.1.332-335.2006.

DOI:10.1128/AAC.50.1.332-335.2006
PMID:16377705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1346773/
Abstract

The antimicrobial properties and the elution characteristics of gentamicin-vancomycin-loaded hip spacers were studied in vivo and in vitro. Vancomycin elution was greater than gentamicin elution. The antibiotic concentrations in vivo were less than those in vitro. Not dependent on implantation duration, growth inhibition by spacers in vitro was observed for 2 weeks. The reason for protracted wound healing cannot be insufficient antibiotic release.

摘要

对载有庆大霉素-万古霉素的髋关节间隔器的抗菌特性和洗脱特性进行了体内和体外研究。万古霉素的洗脱量大于庆大霉素的洗脱量。体内抗生素浓度低于体外。体外观察到间隔器的生长抑制作用持续2周，且不依赖于植入持续时间。伤口愈合延迟的原因不可能是抗生素释放不足。

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