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聚甲基丙烯酸甲酯骨水泥：临床应用中的抗生素洗脱及力学性能

PMMA Bone Cement: Antibiotic Elution and Mechanical Properties in the Context of Clinical Use.

作者信息

von Hertzberg-Boelch Sebastian Philipp, Luedemann Martin, Rudert Maximilian, Steinert Andre F

机构信息

Department of Orthopaedic Surgery, University of Wuerzburg, Koenig-Ludwig-Haus, 11 Brettreichstrasse, 97074 Würzburg, Germany.

Rhön Klinikum, Campus Bad Neustadt, EndoRhoen Center for Joint Replacement, Teaching Hospital of the Phillipps University Marburg, Von Guttenberg Str. 11, 97616 Bad Neustadt, Germany.

出版信息

Biomedicines. 2022 Jul 29;10(8):1830. doi: 10.3390/biomedicines10081830.

DOI:10.3390/biomedicines10081830
PMID:36009376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9404960/
Abstract

This literature review discusses the use of antibiotic loaded polymethylmethacrylate bone cements in arthroplasty. The clinically relevant differences that have to be considered when antibiotic loaded bone cements (ALBC) are used either for long-term implant fixation or as spacers for the treatment of periprosthetic joint infections are outlined. In this context, in vitro findings for antibiotic elution and material properties are summarized and transferred to clinical use.

摘要

这篇文献综述讨论了载抗生素聚甲基丙烯酸甲酯骨水泥在关节置换术中的应用。概述了在将载抗生素骨水泥（ALBC）用于长期植入物固定或作为治疗假体周围关节感染的间隔物时必须考虑的临床相关差异。在此背景下，总结了抗生素洗脱和材料特性的体外研究结果，并将其应用于临床。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b84/9404960/19ef0afa7c02/biomedicines-10-01830-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b84/9404960/19ef0afa7c02/biomedicines-10-01830-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b84/9404960/19ef0afa7c02/biomedicines-10-01830-g001.jpg

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Controlling Antibiotic Release from Polymethylmethacrylate Bone Cement.控制聚甲基丙烯酸甲酯骨水泥中的抗生素释放。
Biomedicines. 2021 Jan 1;9(1):26. doi: 10.3390/biomedicines9010026.
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When to Use Commercially Available Antibiotic Cement: An Ongoing Debate: Commentary on an article by Robert S. Namba, MD, et al.: "Commercially Prepared Antibiotic-Loaded Bone Cement and Infection Risk Following Cemented Primary Total Knee Arthroplasty".
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J Exp Orthop. 2025 May 26;12(2):e70271. doi: 10.1002/jeo2.70271. eCollection 2025 Apr.
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