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1型人类免疫缺陷病毒逆转录酶中的K101P和K103R/V179D突变赋予对非核苷类逆转录酶抑制剂的耐药性。

The K101P and K103R/V179D mutations in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nonnucleoside reverse transcriptase inhibitors.

作者信息

Parkin Neil T, Gupta Soumi, Chappey Colombe, Petropoulos Christos J

机构信息

Monogram Biosciences, Inc., 345 Oyster Point Blvd., South San Francisco, California 94080, USA.

出版信息

Antimicrob Agents Chemother. 2006 Jan;50(1):351-4. doi: 10.1128/AAC.50.1.351-354.2006.

DOI:10.1128/AAC.50.1.351-354.2006
PMID:16377709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1346823/
Abstract

Genotypic patterns associated with nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in the absence of well-characterized resistance mutations were identified using a database (n > 47,000) of phenotype-genotype data. Among samples with no known NNRTI mutations, the most resistant samples contained K101P (n = 35) or a combination of K103R and V179D (n = 41). Site-directed mutagenesis confirmed the importance of these mutations.

摘要

利用一个包含超过47000个表型-基因型数据的数据库，确定了在缺乏明确耐药突变情况下与非核苷类逆转录酶抑制剂（NNRTI）耐药相关的基因型模式。在没有已知NNRTI突变的样本中，耐药性最强的样本含有K101P（n = 35）或K103R与V179D的组合（n = 41）。定点诱变证实了这些突变的重要性。

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