Bourin M, Hascoet M, Mansouri B, Colombel M C, Bradwejn J
GIS Medicament, Faculty of Medicine, Nantes University, France.
J Psychiatry Neurosci. 1992 Jun;17(2):72-7.
The behavioral and clinical profiles of various benzodiazepines after acute and chronic treatment are not well defined and may differ. The aim of this study was to evaluate the behavioral profiles of alprazolam, bromazepam, diazepam and lorazepam in mice after single and repeated (every half-life for seven half-lives) administrations using a stimulation-sedation test (actimeter), a myorelaxation test (rotarod), and an anxiolysis test ("four plates"). A dose range from 0.03 to 4 mg/kg was used. A single administration of alprazolam showed stimulating and anxiolytic effects which diminished after repeated administration. Lorezapam's sedative effect diminished but its anxiolytic effect increased upon repeated administration. Except for lorazepam, the myorelaxing effect of all four drugs increased after repeated treatment. These results suggest that the behavioral profile of benzodiazepines may not be identical during acute and chronic treatment. These differences may be present in clinical treatment and warrant investigation in humans.
各种苯二氮䓬类药物在急性和慢性治疗后的行为和临床特征尚未明确界定，且可能有所不同。本研究的目的是使用刺激-镇静试验（活动计）、肌松试验（转棒试验）和抗焦虑试验（“四板试验”），评估单次和重复给药（每半衰期给药一次，共七个半衰期）后，阿普唑仑、溴西泮、地西泮和劳拉西泮在小鼠中的行为特征。使用的剂量范围为0.03至4mg/kg。单次给予阿普唑仑显示出刺激和抗焦虑作用，重复给药后这些作用减弱。重复给药后，劳拉西泮的镇静作用减弱，但其抗焦虑作用增强。除劳拉西泮外，所有四种药物在重复治疗后的肌松作用均增强。这些结果表明，苯二氮䓬类药物在急性和慢性治疗期间的行为特征可能不相同。这些差异可能存在于临床治疗中，值得在人体中进行研究。
