烯烃复分解反应在生物活性大环化合物合成中的应用。
The application of olefin metathesis to the synthesis of biologically active macrocyclic agents.
作者信息
Van de Weghe Pierre, Eustache Jacques
机构信息
Laboratoire de Chimie Organique et Bioorganique associé au CNRS, Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, 3, rue Alfred Werner, F-68093 Mulhouse Cedex, France.
出版信息
Curr Top Med Chem. 2005;5(15):1495-519. doi: 10.2174/156802605775009748.
Recent developments of the metathesis reaction in the area of biologically active molecules are presented. Scope and limitations of ring-closing metathesis to form medium and large rings are discussed and illustrated by the epothilone synthesis. Applications of the metathesis reaction related to medicinal chemistry, including solid phase synthesis and combinatorial chemistry are presented.
本文介绍了复分解反应在生物活性分子领域的最新进展。通过埃坡霉素的合成，讨论并举例说明了闭环复分解反应形成中环和大环的范围及局限性。还介绍了复分解反应在药物化学中的应用，包括固相合成和组合化学。
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