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高剂量率近距离放射治疗中的在线植入物重建

On-line implant reconstruction in HDR brachytherapy.

作者信息

Kolkman-Deurloo Inger-Karine K, de Kruijf Wilhelmus J M, Levendag Peter C

机构信息

Department of Radiation Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.

出版信息

Radiother Oncol. 2006 Jan;78(1):53-9. doi: 10.1016/j.radonc.2005.12.003. Epub 2005 Dec 27.

Abstract

BACKGROUND AND PURPOSE

To evaluate the accuracy of on-line planning in an Integrated Brachytherapy Unit (IBU) using dedicated image distortion correction algorithms, correcting the geometric distortion and magnetic distortion separately, and to determine the effect of the reconstruction accuracy on clinical treatment plans in terms of deviations in treatment time and dose.

PATIENTS AND METHODS

The reconstruction accuracy has been measured using 20 markers, positioned at well known locations in a QA phantom. Treatment plans of two phantoms representing clinical implant geometries, have been compared with reference plans to determine the effect of the reconstruction accuracy on the treatment plan. Before clinical introduction, treatment plans of three representative patients, based on on-line reconstruction, have been compared with reference plans.

RESULTS

The average reconstruction error for 10 in. images reduces from -0.6 mm (range -2.6 to +1.0 mm) to -0.2 mm (range -1.2 to +0.6 mm) after image distortion correction and for 15 in. images from 0.8 mm (range -0.5 to +3.0 mm) to 0.0 mm (range -0.8 to +0.8 mm). The error in case of eccentric positioning of the phantom, i.e. 0.8 mm (range -1.0 to +3.3 mm), reduces to 0.1 mm (range -0.5 to +0.9 mm). Correction of the image distortions reduces the deviation in the calculated treatment time of maximally 2.7% to less than 0.8% in case of eccentrically positioned clinical phantoms. The deviation in the treatment time or reference dose in the plans based on on-line reconstruction with image distortion correction of the three patient examples is smaller than 0.3%.

CONCLUSIONS

Accurate on-line implant reconstruction using the IBU localiser and dedicated correction algorithms separating the geometric distortion and the magnetic distortion is possible. The results fulfill the minimum requirements as imposed by the Netherlands Commission on Radiation Dosimetry (NCS) without limitations regarding the usable range of the field of view of the image intensifier. However, the C-arm angle is limited to those angles for which magnetic distortion corrections have been obtained.

摘要

背景与目的

使用专门的图像失真校正算法,分别校正几何失真和磁失真,评估一体化近距离放射治疗单元(IBU)中在线计划的准确性,并根据治疗时间和剂量偏差确定重建精度对临床治疗计划的影响。

患者与方法

使用20个标记物测量重建精度,这些标记物放置在质量保证体模中已知位置。将代表临床植入几何形状的两个体模的治疗计划与参考计划进行比较,以确定重建精度对治疗计划的影响。在临床应用前,将基于在线重建的三名代表性患者的治疗计划与参考计划进行比较。

结果

图像失真校正后,10英寸图像的平均重建误差从-0.6毫米(范围为-2.6至+1.0毫米)降至-0.2毫米(范围为-1.2至+0.6毫米),15英寸图像的平均重建误差从0.8毫米(范围为-0.5至+3.0毫米)降至0.0毫米(范围为-0.8至+0.8毫米)。体模偏心定位时的误差,即0.8毫米(范围为-1.0至+3.3毫米),降至0.1毫米(范围为-0.5至+0.9毫米)。图像失真校正将偏心定位的临床体模计算治疗时间的偏差从最大2.7%降低至小于0.8%。在三个患者实例中,基于图像失真校正的在线重建计划的治疗时间或参考剂量偏差小于0.3%。

结论

使用IBU定位器和将几何失真与磁失真分开的专门校正算法,可以进行准确的在线植入物重建。结果满足了荷兰辐射剂量测定委员会(NCS)规定的最低要求,且对图像增强器视野的可用范围没有限制。然而,C形臂角度仅限于已获得磁失真校正的角度。

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