Yasuhara Daisuke, Kojima Shinya, Naruo Tetsuro, Inui Akio
Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima-City 890-8520, Japan.
Psychoneuroendocrinology. 2006 May;31(4):452-8. doi: 10.1016/j.psyneuen.2005.11.002. Epub 2005 Dec 27.
Refeeding outcome is difficult to predict in anorexia nervosa (AN). Because reactive hypoglycemia (RH) during an oral glucose tolerance test (OGTT) correlates with rapid increases of energy intake just before the OGTT in AN patients, this study investigated whether pretreatment laboratory-measured RH episodes might be associated with refeeding progress in this disorder. Forty-six female patients with AN (25 restrictors and 21 binge/purgers) and 11 controls underwent an OGTT before treatment. The patients were divided into groups according to the presence of RH. Thereafter, AN patients underwent nutritional rehabilitation, and weight gain and daily energy intake were evaluated. In both AN subtypes, the RH groups showed more daily energy intake and gained more weight compared with the non-RH groups. The present study found a close relationship between pretreatment laboratory-measured RH episodes and refeeding progress, suggesting that pretreatment laboratory-measured RH episodes may be an important predictor of short-term refeeding outcome in AN.
神经性厌食症（AN）的再喂养结果很难预测。由于口服葡萄糖耐量试验（OGTT）期间的反应性低血糖（RH）与AN患者在OGTT前能量摄入的快速增加相关，本研究调查了治疗前实验室测量的RH发作是否可能与该疾病的再喂养进展有关。46名患有AN的女性患者（25名限制型和21名暴饮暴食/清除型）和11名对照在治疗前接受了OGTT。根据是否存在RH将患者分组。此后，AN患者接受营养康复治疗，并评估体重增加和每日能量摄入情况。在两种AN亚型中，与非RH组相比，RH组的每日能量摄入更多，体重增加也更多。本研究发现治疗前实验室测量的RH发作与再喂养进展之间存在密切关系，表明治疗前实验室测量的RH发作可能是AN短期再喂养结果的重要预测指标。
