人类蛋白质参考数据库——2006年更新版
Human protein reference database--2006 update.
作者信息
Mishra Gopa R, Suresh M, Kumaran K, Kannabiran N, Suresh Shubha, Bala P, Shivakumar K, Anuradha N, Reddy Raghunath, Raghavan T Madhan, Menon Shalini, Hanumanthu G, Gupta Malvika, Upendran Sapna, Gupta Shweta, Mahesh M, Jacob Bincy, Mathew Pinky, Chatterjee Pritam, Arun K S, Sharma Salil, Chandrika K N, Deshpande Nandan, Palvankar Kshitish, Raghavnath R, Krishnakanth R, Karathia Hiren, Rekha B, Nayak Rashmi, Vishnupriya G, Kumar H G Mohan, Nagini M, Kumar G S Sameer, Jose Rojan, Deepthi P, Mohan S Sujatha, Gandhi T K B, Harsha H C, Deshpande Krishna S, Sarker Malabika, Prasad T S Keshava, Pandey Akhilesh
机构信息
Institute of Bioinformatics, International Tech Park, Bangalore 560 066, India.
出版信息
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D411-4. doi: 10.1093/nar/gkj141.
Human Protein Reference Database (HPRD) (http://www.hprd.org) was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein-protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein-protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (http://www.genprot.org), developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data.
人类蛋白质参考数据库（HPRD）（http://www.hprd.org）旨在全面收集蛋白质特征、翻译后修饰（PTM）以及蛋白质-蛋白质相互作用信息。自最初发布以来，该数据库的蛋白质条目已增加到超过20000个，成为有关人类蛋白质的文献衍生蛋白质-蛋白质相互作用（超过30000个）和翻译后修饰（超过8000个）的最大数据库。我们还在HPRD中引入了几个新功能，包括：（i）蛋白质异构体，（ii）增强的搜索选项，（iii）通路注释链接，以及（iv）整合了我们开发的新型浏览器GenProt Viewer（http://www.genprot.org），该浏览器可整合基因组和蛋白质组信息。在生物医学界的持续支持和积极参与下，我们期望HPRD成为人类蛋白质组经过整理的信息的独特来源，并基于基因组、转录组和蛋白质组数据的整合推动生物医学发现。
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