Holmes S A, Cheng C, Whitfield H N
Department of Urology, St Bartholomew's Hospital, London.
Br J Urol. 1992 Jun;69(6):651-5. doi: 10.1111/j.1464-410x.1992.tb15640.x.
The consequences of long-term exposure of synthetic materials to urine have prevented the development of alloplastic replacement of diseased or damaged parts of the urinary tract. Similarly, urethral and ureteric catheters require regular replacement if the complications of encrustation and blockage are to be avoided. The mechanism of encrustation is not understood completely and thus it is unclear why certain materials appear better able to resist encrustation. This study has involved the development of a new encrustation model to provide a reproducible and quantitative assessment of the susceptibility of polymers to encrustation. This model will allow beneficial characteristics of co-polymer design to be recognised, with the aim of finding new materials that are tolerant of exposure to urine. Results of co-polymers examined show that the incorporation of fluorine-containing components confers significant resistance to the formation of encrustation. It is suggested that the physico-chemical properties of polymer surfaces may be important determinants of resistance to encrustation.
合成材料长期暴露于尿液中的后果阻碍了尿路病变或受损部位的异体替代物的发展。同样地，如果要避免结壳和堵塞并发症，尿道和输尿管导管需要定期更换。结壳的机制尚未完全了解，因此不清楚为什么某些材料似乎更能抵抗结壳。本研究开发了一种新的结壳模型，以对聚合物的结壳敏感性进行可重复的定量评估。该模型将有助于识别共聚物设计的有益特性，目的是找到能够耐受尿液暴露的新材料。对共聚物的检测结果表明，含氟成分的加入赋予了显著的抗结壳形成能力。有人认为，聚合物表面的物理化学性质可能是抗结壳的重要决定因素。
