Tunney M M, Keane P F, Gorman S P
Pharmaceutical Devices Group, School of Pharmacy, The Queen's University of Belfast, United Kingdom.
J Biomed Mater Res. 1997 Summer;38(2):87-93. doi: 10.1002/(sici)1097-4636(199722)38:2<87::aid-jbm2>3.0.co;2-c.
Encrustation of biomaterials employed in the urinary tract remains a major problem resulting in obstruction or blockage of catheters and stents. Therefore, resistance to encrustation is a desirable feature of biomaterials employed in such devices. The novel assessment of biomaterial encrustation employing a continuous flow model based on a modified Robbins device is described. Artificial urine was used in conjunction with 5% CO2 to simulate the physiological environment within the upper urinary tract. The widely used urinary device biomaterials, silicone and polyurethane, were investigated in the model for hydroxyapatite and struvite encrustation. Scanning electron microscopy, energy dispersive X-ray analysis, and atomic absorption spectroscopy all showed that silicone was less prone to encrustation than polyurethane and that hydroxyapatite deposition was predominant on both surfaces. The model has the advantage that a large number of biomaterials may be investigated simultaneously because several Robbins devices may be placed in parallel. The model is recommended for comparative evaluation of biomaterial candidates for use in urinary tract devices.
用于泌尿道的生物材料结壳仍然是一个主要问题，会导致导管和支架的阻塞或堵塞。因此，抗结壳是此类装置中使用的生物材料的一个理想特性。本文描述了一种基于改良Robbins装置的连续流动模型对生物材料结壳的新评估方法。使用人工尿液并结合5%二氧化碳来模拟上泌尿道内的生理环境。在该模型中研究了广泛使用的泌尿装置生物材料硅酮和聚氨酯的羟基磷灰石和鸟粪石结壳情况。扫描电子显微镜、能量色散X射线分析和原子吸收光谱均表明，硅酮比聚氨酯更不易结壳，且两个表面上均以羟基磷灰石沉积为主。该模型的优点是可以同时研究大量生物材料，因为可以并行放置多个Robbins装置。推荐使用该模型对用于泌尿道装置的生物材料候选物进行比较评估。
