Shaw H L
Abbott Laboratories, Abbott Park, Illinois.
Cancer. 1992 Aug 15;70(4 Suppl):993-7.
Oncologic therapy demands technologic sophistication to meet the clinical challenges of proper drug administration for chemotherapeutic agents, pain management, antibiotics, hydration, antiemetic drugs, and total parenteral nutrition. Drug administration systems for patient-controlled analgesia include benefits of improved pain control, minimal adverse reactions, lower doses compared with conventional therapy, a high degree of patient acceptance, reduced labor costs, and achievable home therapy. System advances have made epidural, intrathecal, intravenous with bolus capability, and regional or implantable administration possible. In chemotherapy, protracted drug infusions and considerations of circadian rhythms, sequences, and cytostatic treatment will be enhanced further by automated programmable pumps that can meet the challenges of complex protocols. Multidrug antibiotic treatments also are a reality. Electronic drug administration will continue to meet the challenges of site-specific agents and complex dosing regimens to provide therapy for the patient with cancer to achieve an efficacious safe acceptable efficient cost-benefit ratio.
肿瘤治疗需要先进的技术来应对化疗药物、疼痛管理、抗生素、补液、止吐药物及全胃肠外营养等给药方面的临床挑战。患者自控镇痛的给药系统具有诸多优势，包括改善疼痛控制、不良反应最小化、与传统治疗相比剂量更低、患者接受度高、劳动力成本降低以及可实现家庭治疗。系统的进步使硬膜外、鞘内、具备推注功能的静脉内以及区域或植入式给药成为可能。在化疗中，可满足复杂方案挑战的自动化可编程泵将进一步加强持续药物输注以及对昼夜节律、给药顺序和细胞抑制治疗的考量。多种抗生素联合治疗也已成为现实。电子给药将继续应对针对特定部位药物和复杂给药方案的挑战，为癌症患者提供治疗，以实现有效、安全、可接受且高效的成本效益比。
