Song Yang, Wang Ping, Wu Juanjuan, Zhou Xiang, Zhang Xiao-Lian, Weng Linhong, Cao Xiaoping, Liang Feng
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China.
Bioorg Med Chem Lett. 2006 Mar 15;16(6):1660-4. doi: 10.1016/j.bmcl.2005.12.007. Epub 2005 Dec 27.
Three water-soluble DNA cross-linking phenol quaternary ammonium derivatives 3, 4, and 5 could inhibit the transcription in vitro by photoactivation. DNA interstrand cross-linking action might be the key factor to inhibit transcription by these compounds. Further tumor cell apoptosis was observed by flow cytometry it indicated that cross-linking agent 5 could significantly induce the late apoptosis of tumor cells.
三种水溶性DNA交联酚季铵衍生物3、4和5可通过光活化在体外抑制转录。DNA链间交联作用可能是这些化合物抑制转录的关键因素。通过流式细胞术观察到进一步的肿瘤细胞凋亡，表明交联剂5可显著诱导肿瘤细胞的晚期凋亡。
