Hancu Ileana, Dixon W Thomas, Woods Mark, Vinogradov Elena, Sherry A Dean, Lenkinski Robert E
GE Global Research Center, Niskayuna, NY, USA.
Acta Radiol. 2010 Oct;51(8):910-23. doi: 10.3109/02841851.2010.502126.
In this review we describe the status of development for a new class of magnetic resonance (MR) contrast agents, based on chemical exchange saturation transfer (CEST). The mathematics and physics relevant to the description of the CEST effect in MR are presented in an appendix published in the online version only. We discuss the issues arising when translating in vitro results obtained with CEST agents to using these MR agents in in vivo model studies and in humans. Examples are given on how these agents are imaged in vivo. We summarize the status of development of these CEST agents, and speculate about the next steps that may be taken towards the demonstration of CEST MR imaging in clinical applications.
在本综述中，我们描述了基于化学交换饱和转移（CEST）的新型磁共振（MR）造影剂的开发状况。与MR中CEST效应描述相关的数学和物理内容仅在在线版本发表的附录中呈现。我们讨论了将CEST造影剂在体外获得的结果转化为在体内模型研究和人体中使用这些MR造影剂时出现的问题。给出了这些造影剂在体内成像方式的示例。我们总结了这些CEST造影剂的开发状况，并推测在临床应用中证明CEST MR成像可能采取的后续步骤。
