Narayana Ponnada A
Department of Interventional Imaging, University of Texas Medical School at Houston, TX 77030, USA.
J Neuroimaging. 2005;15(4 Suppl):46S-57S. doi: 10.1177/1051228405284200.
In addition to providing information on tissue structure, magnetic resonance (MR) technology offers the potential to investigate tissue metabolism and function. MR spectroscopy (MRS) offers a wealth of data on the biochemistry of a selected brain tissue volume, which represent potential surrogate markers for the pathology underlying multiple sclerosis (MS). In particular, the N-acetylaspartate peak in an MR spectrum is a putative marker of neuronal and axonal integrity, and the choline peak appears to reflect cell-membrane metabolism. On this basis, a diminished N-acetylaspartate peak is interpreted to represent neuronal/axonal dysfunction or loss, and an elevated choline peak represents heightened cell-membrane turnover, as seen in demyelination, remyelination, inflammation, or gliosis. Therefore, MRS may provide a unique tool to evaluate the severity of MS, establish a prognosis, follow disease evolution, understand its pathogenesis, and evaluate the efficacy of therapeutic interventions, which complements the information obtained from the various forms of assessment made by conventional MR imaging.
除了提供有关组织结构的信息外，磁共振（MR）技术还具有研究组织代谢和功能的潜力。磁共振波谱（MRS）可提供有关选定脑组织结构生物化学的大量数据，这些数据代表了多发性硬化症（MS）潜在病理的替代标志物。特别是，MR谱中的N-乙酰天门冬氨酸峰被认为是神经元和轴突完整性的标志物，而胆碱峰似乎反映了细胞膜代谢。在此基础上，N-乙酰天门冬氨酸峰降低被解释为代表神经元/轴突功能障碍或丧失，胆碱峰升高代表细胞膜更新加快，如在脱髓鞘、再髓鞘化、炎症或胶质增生中所见。因此，MRS可能提供一种独特的工具来评估MS的严重程度、建立预后、跟踪疾病进展、了解其发病机制以及评估治疗干预的效果，这补充了从传统MR成像的各种评估形式中获得的信息。
