Hill S M, Spriggs L L, Simon M A, Muraoka H, Blask D E
Tulane University, School of Medicine, Department of Anatomy, New Orleans, Louisiana 70112.
Cancer Lett. 1992 Jul 10;64(3):249-56. doi: 10.1016/0304-3835(92)90050-6.
The pineal hormone, melatonin, was examined for its capacity to modulate the proliferation of a panel of human breast cancer cell lines. Melatonin inhibited, to a varying extent, the proliferation of all three estrogen-responsive cell lines, but had no effect on estrogen-insensitive breast tumor cell lines. Melatonin was also able to specifically block estrogen-induced proliferation in MCF-7 breast cancer cells. However, this action was abolished in the presence of tamoxifen. Therefore, it appears that the antiproliferative effects of melatonin are mediated through the estrogen-response pathway.
对松果体激素褪黑素调节一组人乳腺癌细胞系增殖的能力进行了研究。褪黑素在不同程度上抑制了所有三种雌激素反应性细胞系的增殖，但对雌激素不敏感的乳腺肿瘤细胞系没有影响。褪黑素还能够特异性地阻断MCF-7乳腺癌细胞中雌激素诱导的增殖。然而，在他莫昔芬存在的情况下，这种作用被消除。因此，褪黑素的抗增殖作用似乎是通过雌激素反应途径介导的。
