Paulsen Jane S, Nehl Carissa, Hoth Karin Ferneyhough, Kanz Jason E, Benjamin Michelle, Conybeare Rachel, McDowell Bradley, Turner Beth
University of Iowa, 1-305 Medical Education Building, Iowa City, IA 52242, USA.
J Neuropsychiatry Clin Neurosci. 2005 Fall;17(4):496-502. doi: 10.1176/jnp.17.4.496.
Individuals with manifest Huntington's disease (HD) were interviewed with regard to the presence, frequency, and severity of depression symptoms to better characterize depressed mood across the disease course in HD. Rates of depression were more than twice that found in the general population. One-half reported that they had sought treatment for depression, and more than 10% reported having at least one suicide attempt. The proportion of HD patients endorsing significant depression diminished with disease progression. Despite the public health impact of depression, available treatments are underutilized in HD, and research is needed to document the efficacy and effectiveness of standard depression treatments in this population.
对患有明显亨廷顿舞蹈症（HD）的个体就抑郁症状的存在、频率和严重程度进行了访谈，以更好地描述HD病程中抑郁情绪的特征。抑郁症的发病率是普通人群的两倍多。一半的人报告说他们曾寻求过抑郁症治疗，超过10%的人报告至少有过一次自杀企图。随着疾病进展，认可有明显抑郁症的HD患者比例有所下降。尽管抑郁症对公共卫生有影响，但HD患者对现有治疗方法的利用率较低，需要开展研究以证明标准抑郁症治疗方法对该人群的疗效和有效性。
