Modi Ketan, Santani D D, Goyal R K, Bhatt P A
Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad-380009, Gujarat, India.
Biol Trace Elem Res. 2006 Jan;109(1):25-34. doi: 10.1385/BTER:109:1:025.
Although coenzyme Q10 (CoQ10) is a component of the oxidative phosphorylation process in mitochondria that converts the energy in carbohydrates and fatty acids into ATP to drive cellular machinery and synthesis, its effect in type I diabetes is not clear. We have studied the effect of 4 wk of treatment with CoQ10 (10 mg/kg, ip, daily) in streptozotocin (STZ)-induced (40 mg/kg, iv in adult rats) type I diabetes rat models. Treatment with CoQ10 produced a significant decrease in elevated levels of glucose, cholesterol, triglycerides, very-low-density lipoprotein, low-density lipoprotein, and atherogenic index and increased high-density lipoprotein cholesterol levels in diabetic rats. CoQ10 treatment significantly decreased the area under the curve over 120 min for glucose in diabetic rats, without affecting serum insulin levels and the area under the curve over 120 min for insulin in diabetic rats. CoQ10 treatment also reduced lipid peroxidation and increased antioxidant parameters like superoxide dismutase, catalase, and glutathione in the liver homogenates of diabetic rats. CoQ10 also lowered the elevated blood pressure in diabetic rats. In conclusion, CoQ10 treatment significantly improved deranged carbohydrate and lipid metabolism of experimental chemically induced diabetes in rats. The mechanism of its beneficial effect appears to be its antioxidant property.
尽管辅酶Q10（CoQ10）是线粒体氧化磷酸化过程的一个组成部分，该过程将碳水化合物和脂肪酸中的能量转化为ATP以驱动细胞机制和合成，但它在I型糖尿病中的作用尚不清楚。我们研究了在链脲佐菌素（STZ）诱导（成年大鼠静脉注射40mg/kg）的I型糖尿病大鼠模型中，连续4周每天腹腔注射10mg/kg辅酶Q10的治疗效果。辅酶Q10治疗使糖尿病大鼠体内升高的葡萄糖、胆固醇、甘油三酯、极低密度脂蛋白、低密度脂蛋白水平以及动脉粥样硬化指数显著降低，并使高密度脂蛋白胆固醇水平升高。辅酶Q10治疗显著降低了糖尿病大鼠120分钟内葡萄糖曲线下面积，而不影响血清胰岛素水平以及糖尿病大鼠120分钟内胰岛素曲线下面积。辅酶Q10治疗还减少了脂质过氧化，并增加了糖尿病大鼠肝脏匀浆中的超氧化物歧化酶、过氧化氢酶和谷胱甘肽等抗氧化参数。辅酶Q10还降低了糖尿病大鼠升高的血压。总之，辅酶Q10治疗显著改善了实验性化学诱导糖尿病大鼠紊乱的碳水化合物和脂质代谢。其有益作用的机制似乎是其抗氧化特性。
