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爱沙尼亚注射吸毒人群中艾滋病毒、乙型肝炎病毒和丙型肝炎病毒的监测：用于公共卫生监测的注射器检测的敏感性和特异性

Surveillance of HIV, hepatitis B virus, and hepatitis C virus in an estonian injection drug-using population: sensitivity and specificity of testing syringes for public health surveillance.

作者信息

Uuskula Anneli, Heimer Robert, Dehovitz Jack, Fischer Krista, McNutt Louise-Anne

机构信息

Department of Public Health, University of Tartu, Estonia.

出版信息

J Infect Dis. 2006 Feb 1;193(3):455-7. doi: 10.1086/499436. Epub 2005 Dec 22.

DOI:10.1086/499436
PMID:16388495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2917983/
Abstract

Surveillance of bloodborne infections among injection drug users (IDUs) can be accomplished by determining the presence of pathogen markers in used syringes. Parallel testing of returned syringes and venous blood from IDUs was conducted to detect antibodies to human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). Syringe surveillance for HIV yielded a sensitivity and specificity of 92% and 89%, respectively, and provided a reasonable estimate of the prevalence of HIV among participants. Because sensitivity for HBV (34%) and HCV (55%) was low, syringe testing may be useful for surveillance of hepatitis over time but not for estimation of prevalence.

摘要

通过检测用过的注射器中病原体标志物，可以实现对注射吸毒者（IDU）血源感染的监测。对IDU归还的注射器和静脉血进行平行检测，以检测针对人类免疫缺陷病毒（HIV）、乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的抗体。HIV的注射器监测敏感性和特异性分别为92%和89%，并为参与者中HIV的流行率提供了合理估计。由于HBV（34%）和HCV（55%）的敏感性较低，注射器检测可能有助于长期监测肝炎，但不适用于估计流行率。