ω-3脂肪酸用于产后抑郁症的随机剂量范围试验性研究
Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression.
作者信息
Freeman M P, Hibbeln J R, Wisner K L, Brumbach B H, Watchman M, Gelenberg A J
机构信息
Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ 85724-5002, USA.
出版信息
Acta Psychiatr Scand. 2006 Jan;113(1):31-5. doi: 10.1111/j.1600-0447.2005.00660.x.
OBJECTIVE
Postpartum depression (PPD) affects 10-15% of mothers. Omega-3 fatty acids are an intriguing potential treatment for PPD.
METHOD
The efficacy of omega-3 fatty acids for PPD was assessed in an 8-week dose-ranging trial. Subjects were randomized to 0.5 g/day (n = 6), 1.4 g/day (n = 3), or 2.8 g/day (n = 7).
RESULTS
Across groups, pretreatment Edinburgh Postnatal Depression Scale (EPDS) and Hamilton Rating Scale for Depression (HRSD) mean scores were 18.1 and 19.1 respectively; post-treatment mean scores were 9.3 and 10.0. Percent decreases on the EPDS and HRSD were 51.5% and 48.8%, respectively; changes from baseline were significant within each group and when combining groups. Groups did not significantly differ in pre- or post-test scores, or change in scores. The treatment was well tolerated.
CONCLUSION
This study was limited by small sample size and lack of placebo group. However, these results support further study of omega-3 fatty acids as a treatment for PPD.
目的
产后抑郁症（PPD）影响10%至15%的母亲。ω-3脂肪酸是一种有吸引力的PPD潜在治疗方法。
方法
在一项为期8周的剂量范围试验中评估了ω-3脂肪酸对PPD的疗效。受试者被随机分为每日0.5克组（n = 6）、1.4克组（n = 3）或2.8克组（n = 7）。
结果
各治疗组中，治疗前爱丁堡产后抑郁量表（EPDS）和汉密尔顿抑郁评定量表（HRSD）的平均得分分别为18.1和19.1；治疗后的平均得分分别为9.3和10.0。EPDS和HRSD得分的下降百分比分别为51.5%和48.8%；每组内及合并组后与基线相比的变化均具有显著性。各治疗组在治疗前、后的得分或得分变化方面无显著差异。该治疗耐受性良好。
结论
本研究受样本量小和缺乏安慰剂组的限制。然而，这些结果支持进一步研究将ω-3脂肪酸作为PPD的一种治疗方法。
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