Freeman M P
Women's Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ 85724-5002, USA.
Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):291-7. doi: 10.1016/j.plefa.2006.07.007. Epub 2006 Aug 22.
Perinatal depression refers to major depression in the context of pregnancy and postpartum. In consideration of its prevalence and consequences, the treatment and prevention of perinatal depression should be important public health priorities. Omega-3 fatty acids are attractive for consideration in perinatal women, due to known health benefits for the mother and baby. Antidepressant medications may pose risks in utero and in breastfeeding.
MEDLINE and manual searches were conducted.
Epidemiological and preclinical data support a role of omega-3 fatty acids in perinatal depression. Two studies failed to support a role of omega-3 fatty acids for postpartum depression prophylaxis, although one included a small sample, and the other utilized a low dosage. Two pilot studies suggest good tolerability and potential efficacy in the acute treatment of perinatal depression.
Further research studies are warranted to determine the role of omega-3 fatty acids in the treatment of perinatal depression.
围产期抑郁症是指在孕期和产后发生的重度抑郁症。鉴于其患病率和后果，围产期抑郁症的治疗和预防应成为重要的公共卫生优先事项。由于已知对母婴健康有益，ω-3脂肪酸值得围产期妇女考虑。抗抑郁药物在子宫内和母乳喂养期间可能存在风险。
进行了医学文献数据库（MEDLINE）检索和手工检索。
流行病学和临床前数据支持ω-3脂肪酸在围产期抑郁症中的作用。两项研究未能支持ω-3脂肪酸对产后抑郁症预防的作用，尽管一项研究样本量小，另一项研究使用的剂量低。两项初步研究表明，ω-3脂肪酸在围产期抑郁症的急性治疗中耐受性良好且可能有效。
有必要进行进一步的研究以确定ω-3脂肪酸在围产期抑郁症治疗中的作用。
