胺氟化物与氟化亚锡联合对口腔念珠菌属的体外抗真菌作用
In vitro antifungal effect of amine fluoride-stannous fluoride combination on oral Candida species.
作者信息
Meurman J H, Kari K, Waltimo T, Kotiranta A, Inkeri J, Samaranayake L P
机构信息
Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland.
出版信息
Oral Dis. 2006 Jan;12(1):45-50. doi: 10.1111/j.1601-0825.2005.01156.x.
OBJECTIVE
The combination of amine fluoride and stannous fluoride (AmF/SnF2) was, by chance, found to be antifungal in a clinical trial. This study investigated its effect on pathogenic Candida species with the hypothesis that the antifungal action on different species is variable.
MATERIALS AND METHODS
Growth inhibition effect of Meridol mouth rinse which contains 250 ppm AmF/SnF2 was evaluated on 43 reference and clinical strains of Candida albicans, C. dubliniensis, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis, and C. tropicalis. Meridol base solution without AmF/SnF2 was used as a negative control.
RESULTS
Undiluted Meridolmouth rinse killed most study strains within a few minutes. In ascending order, C. parapsilosis, C. tropicalis, C. albicans, C. glabrata, C. krusei and C. dubliniensis showed higher resistance against AmF/SnF2 than C. guilliermondii.
CONCLUSION
AmF/SnF2 could be used as a potent adjunct to antifungal therapy for oral yeasts. Although different Candida species demonstrated variable sensitivity the most prevalent oral yeast C. albicans appeared sensitive to the AmF/SnF2 combination.
目的
在一项临床试验中偶然发现胺氟化物与氟化亚锡（AmF/SnF2）的组合具有抗真菌作用。本研究调查了其对致病性念珠菌属的影响，并假设其对不同菌种的抗真菌作用存在差异。
材料与方法
评估了含有250 ppm AmF/SnF2的Meridol漱口水对43株白色念珠菌、都柏林念珠菌、光滑念珠菌、季也蒙念珠菌、克柔念珠菌、近平滑念珠菌和热带念珠菌的参考菌株及临床菌株的生长抑制作用。将不含AmF/SnF2的Meridol基础溶液用作阴性对照。
结果
未稀释的Meridol漱口水在几分钟内杀死了大多数研究菌株。按抗性由低到高排序，近平滑念珠菌、热带念珠菌、白色念珠菌、光滑念珠菌、克柔念珠菌和都柏林念珠菌对AmF/SnF2的抗性高于季也蒙念珠菌。
结论
AmF/SnF2可作为口服酵母菌抗真菌治疗的有效辅助药物。尽管不同念珠菌种表现出不同的敏感性，但最常见的口腔酵母菌白色念珠菌似乎对AmF/SnF2组合敏感。
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