Horwitz Jacob, Machtei Eli E, Zuabi Otman, Peled Micha
Unit of Periodontology, Department of Oral & Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel.
J Periodontol. 2005 Mar;76(3):334-40. doi: 10.1902/jop.2005.76.3.334.
The growing popularity of non-submerged dental implants in recent years requires a greater emphasis on microbial plaque control. Chlorhexidine (CHX), the most commonly used mouthwash in implant surgery, is sometimes associated with tooth staining and alteration in taste perception. Amine fluoride/stannous fluoride (AmF/SnF2) mouthwash has been shown to have anti-infective properties; however, it has not been tested as an adjunct anti-infective means in non-submerged dental implants. The purpose of this trial was to compare AmF/SnF2 and CHX mouthwashes as adjuncts to single-stage dental implants.
Thirty-three patients aged 34 to 79 (mean 54.30 +/- 8.69 SD) requiring dental implants were accepted into the study. Following comprehensive periodontal therapy patients received one to three non-submerged dental implants (maxilla: 17; mandible: 45; anterior: 3, posterior: 59). After surgery patients were given analgesics and antibiotics as well as 2,400 ml of coded mouthwash bottles previously randomized between the two above mentioned formulations. Clinical and radiographic parameters were recorded at baseline and 3 and 12 months post-surgery.
Twelve-month survival rates were 100% and 92.9% for the AmF/SnF2 and CHX groups, respectively. Compliance was slightly higher in the AmF/SnF2 group (84.35% +/- 3.39% versus 78.15% +/- 4.59% SE) but statistically similar. There was no statistically significant difference between the AmF/SnF2 and CHX groups in staining index at 3 months (1.519 +/- 0.22 versus 1.457 +/- 0.24 SE) and patient subjective evaluation of the mouthwashes. Radiographic bone loss was 0.79 +/- 0.23 and 1 +/- 0.13 SE at 3 months and 1.06 +/- 0.13 and 1.27 +/- 0.25 at 12 months for the CHX and AmF/SnF2 groups, respectively; the difference was statistically insignificant (P = 0.388 and 0.504, respectively).
Both CHX and AmF/SnF2 mouthwashes can be used post-surgically after one-stage implant surgery.
近年来，非潜入式牙种植体越来越受欢迎，这就需要更加重视微生物菌斑的控制。洗必泰（CHX）是种植手术中最常用的漱口水，但有时会导致牙齿染色和味觉改变。胺氟化物/氟化亚锡（AmF/SnF2）漱口水已被证明具有抗感染特性；然而，它尚未作为非潜入式牙种植体的辅助抗感染手段进行测试。本试验的目的是比较AmF/SnF2漱口水和CHX漱口水作为单阶段牙种植体辅助手段的效果。
33名年龄在34至79岁（平均54.30±8.69标准差）需要进行牙种植的患者被纳入研究。在接受全面的牙周治疗后，患者接受了一至三颗非潜入式牙种植体（上颌：17颗；下颌：45颗；前部：3颗，后部：59颗）。术后，患者接受了镇痛药、抗生素以及2400毫升预先在上述两种配方之间随机分配的编码漱口水。在基线、术后3个月和12个月记录临床和影像学参数。
AmF/SnF2组和CHX组的12个月生存率分别为100%和92.9%。AmF/SnF2组的依从性略高（84.35%±3.39%对78.15%±4.59%标准误），但在统计学上相似。在3个月时，AmF/SnF2组和CHX组的染色指数（1.519±0.22对1.457±0.24标准误）以及患者对漱口水的主观评价之间没有统计学上的显著差异。CHX组和AmF/SnF2组在3个月时的影像学骨丢失分别为0.79±0.23和1±0.13标准误，在12个月时分别为1.06±0.13和1.27±0.25；差异无统计学意义（P分别为0.388和0.504）。
CHX漱口水和AmF/SnF2漱口水均可在一期种植手术后用于术后护理。
