Morley J E, Kim M J, Haren M T, Kevorkian R, Banks W A
GRECC, VA Medical Center, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA.
Aging Male. 2005 Sep-Dec;8(3-4):135-40. doi: 10.1080/13685530500277232.
Frailty occurs in aging males for a variety of reasons. It is less common in males than females. Diseases which are particularly associated with frailty are diabetes mellitus, atherosclerosis, anemia and chronic obstructive pulmonary disease. Insulin resistance syndrome plays a pathogenetic role in the "fat-frail" syndrome. Sarcopenia occurs predominantly because of hormone deficiency and cytokine excess. Pain and anorexia are also associated with frailty. Stem cell research represents a potential promise for the treatment of frailty.
男性衰弱的发生有多种原因。在男性中，衰弱比女性少见。与衰弱特别相关的疾病有糖尿病、动脉粥样硬化、贫血和慢性阻塞性肺疾病。胰岛素抵抗综合征在“肥胖-衰弱”综合征中起致病作用。肌肉减少症主要是由于激素缺乏和细胞因子过多所致。疼痛和厌食也与衰弱有关。干细胞研究为衰弱的治疗带来了潜在希望。
