Aldrighi José M, Calvoso-Júnior Roberto, Alecrin Israel N, Trombetta Ivani C, Negrão Carlos E
Women's Climacteric Health Ambulatory, Public Health School, University of São Paulo, São Paulo, Brazil.
Gynecol Endocrinol. 2005 Dec;21(6):324-9. doi: 10.1080/09513590500430831.
We tested the hypothesis that estrogen replacement (2 mg estradiol/day, orally for 90 days) would improve cardiopulmonary and functional capacities in postmenopausal women.
Twenty-three postmenopausal and sedentary women were divided into estrogen replacement (n = 13, 57 +/- 2 years) and placebo control (n = 10, 58 +/- 2 years) groups. They performed a cardiopulmonary exercise test before and after the intervention.
Baseline measurements were similar between groups. Blood pressure and heart rate at rest and during exercise were unchanged by estrogen treatment, and estrogen did not alter pulmonary measurements at rest and during exercise. Oxygen consumption at anaerobic threshold, respiratory compensation point and peak exercise were lower after estrogen replacement, despite the unchanged workload and exercise time to exhaustion. In the placebo control group, no change in peak oxygen consumption, workload and time to exhaustion was found.
Estrogen does not change cardiopulmonary responses to submaximal and maximal exercise in postmenopausal women. In addition, estrogen fails to improve exercise capacity in postmenopausal women.
我们检验了如下假设，即雌激素替代治疗（每天口服2毫克雌二醇，持续90天）可改善绝经后女性的心肺功能和运动能力。
23名绝经后久坐不动的女性被分为雌激素替代治疗组（n = 13，年龄57±2岁）和安慰剂对照组（n = 10，年龄58±2岁）。她们在干预前后进行了心肺运动试验。
两组的基线测量值相似。雌激素治疗未改变静息及运动时的血压和心率，且雌激素未改变静息及运动时的肺部测量值。尽管工作量和运动至疲惫的时间未变，但雌激素替代治疗后无氧阈、呼吸补偿点及运动峰值时的耗氧量降低。在安慰剂对照组中，未发现峰值耗氧量、工作量及运动至疲惫时间有变化。
雌激素不会改变绝经后女性对次最大强度和最大强度运动的心肺反应。此外，雌激素无法改善绝经后女性的运动能力。
