Fogelberg Monika, Löfman Ida, Carlström Kjell, Freyschuss Anna, Henriksson Peter
Department of Medicine, Ersta Hospital, Stockholm, Sweden.
Acta Obstet Gynecol Scand. 2006;85(6):736-40. doi: 10.1080/00016340600589602.
To assess the acute effect of a single dose of 10 mg oral micronized 17beta-estradiol on microcirculation in postmenopausal women with and without coronary artery disease and its potential influence on exercise capacity.
Postmenopausal women (n=11) with coronary artery disease had symptoms of ischemic heart disease and at least 1 mm ST depression at exercise. Microcirculation was examined by vital microscopy, with and without the acute administration of estrogen in a placebo-controlled cross-over design. Exercise test was performed on bicycle. The microcirculatory findings were contrasted to those in 14 healthy postmenopausal women.
17Beta-estradiol in serum and blood flow velocity increased significantly after acute oral estrogen administration both in women with coronary artery disease (p<0.001) and in healthy women (p<0.0001), with no significant difference between the two groups. No effect on exercise capacity or ST depression at exercise was detected.
Previously reported data that a single dose of estrogen administered to postmenopausal women results in positive effects on exercise was not reproduced. An increased peripheral microvascular flow velocity was detected in women with coronary artery disease and this increase was not accompanied by an increased exercise capacity.
评估单剂量10毫克口服微粒化17β-雌二醇对患有和未患有冠状动脉疾病的绝经后女性微循环的急性影响及其对运动能力的潜在影响。
患有冠状动脉疾病的绝经后女性（n = 11）有缺血性心脏病症状，运动时至少有1毫米ST段压低。采用安慰剂对照交叉设计，在给予和未给予雌激素急性给药的情况下，通过活体显微镜检查微循环。在自行车上进行运动试验。将微循环结果与14名健康绝经后女性的结果进行对比。
急性口服雌激素后，患有冠状动脉疾病的女性（p < 0.001）和健康女性（p < 0.0001）血清中的17β-雌二醇和血流速度均显著增加，两组之间无显著差异。未检测到对运动能力或运动时ST段压低有影响。
先前报道的给绝经后女性单剂量雌激素对运动有积极影响的数据未得到重现。在患有冠状动脉疾病的女性中检测到外周微血管血流速度增加，且这种增加并未伴随着运动能力的提高。
