Heart Institute (InCor), University of São Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44 Cerqueira Cesar, São Paulo SP CEP 05403-904, Brazil.
Eur J Heart Fail. 2010 Jan;12(1):58-65. doi: 10.1093/eurjhf/hfp168.
We compared the effects of exercise training on neurovascular control and functional capacity in men and women with chronic heart failure (HF).
Forty consecutive HF outpatients from the Heart Institute, University of Sao Paulo, Brazil were divided into the following four groups matched by age: men exercise-trained (n = 12), men untrained (n = 10), women exercise-trained (n = 9), women untrained (n = 9). Maximal exercise capacity was determined from a maximal progressive exercise test on a cycle ergometer. Forearm blood flow was measured by venous occlusion plethysmography. Muscle sympathetic nerve activity (MSNA) was recorded directly using the technique of microneurography. There were no differences between groups in any baseline parameters. Exercise training produced a similar reduction in resting MSNA (P = 0.000002) and forearm vascular resistance (P = 0.0003), in men and women with HF. Peak VO(2) was similarly increased in men and women with HF (P = 0.0003) and VE/VCO(2) slope was significantly decreased in men and women with HF (P = 0.0007). There were no significant changes in left-ventricular ejection fraction in men and women with HF.
The benefits of exercise training on neurovascular control and functional capacity in patients with HF are independent of gender.
我们比较了运动训练对慢性心力衰竭（HF）男性和女性患者神经血管控制和功能能力的影响。
巴西圣保罗大学心脏研究所的 40 名连续慢性心力衰竭门诊患者按年龄分为以下四组：男性运动训练组（n = 12）、男性未训练组（n = 10）、女性运动训练组（n = 9）、女性未训练组（n = 9）。最大运动能力是通过在自行车测功计上进行最大递增运动试验来确定的。前臂血流通过静脉闭塞容积描记法测量。肌肉交感神经活动（MSNA）通过微神经记录技术直接记录。HF 患者各组间任何基线参数均无差异。运动训练导致 HF 男性和女性的静息 MSNA（P = 0.000002）和前臂血管阻力（P = 0.0003）相似降低。HF 男性和女性的峰值 VO2 均相似增加（P = 0.0003），HF 男性和女性的 VE/VCO2 斜率显著降低（P = 0.0007）。HF 男性和女性的左心室射血分数均无明显变化。
运动训练对 HF 患者神经血管控制和功能能力的益处与性别无关。
