Wang Hong, Lu Lei, Zhu Shiyun, Li Yahong, Cai Weimin
School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Curr Microbiol. 2006 Jan;52(1):1-5. doi: 10.1007/s00284-005-0040-z. Epub 2006 Jan 2.
We assessed the phototoxicity of a series of xanthene derivatives against E. coli, S. aureus, and S. cerevisiae, measured the physicochemical properties of the photosensitizers, and found the relationship between them. Without illumination, the dyes tested showed almost the same level of inherent toxicity to the same organism, which showed the inherent toxicity of dyes was primarily dependent on the structure of parent molecule. Upon illumination, the photosensitizers showed obvious phototoxicity to all organisms. The dyes showed stronger phototoxicity to Gram-positive bacteria. With the increasing number of halogen substituents, the singlet oxygen yields increased and the phototoxic activity increased too. There was no obvious correlation between relative lipophilicity and activity in the current study. Our results showed xanthenes had the potential to act as alternatives to conventional antimicrobial compounds and also could be used for the decontamination of microbially polluted waters.
我们评估了一系列呫吨衍生物对大肠杆菌、金黄色葡萄球菌和酿酒酵母的光毒性，测量了光敏剂的物理化学性质，并发现了它们之间的关系。在无光照条件下，所测试的染料对同一生物体显示出几乎相同水平的固有毒性，这表明染料的固有毒性主要取决于母体分子的结构。光照后，光敏剂对所有生物体均表现出明显的光毒性。这些染料对革兰氏阳性菌显示出更强的光毒性。随着卤素取代基数量的增加，单线态氧产率增加，光毒性活性也增加。在本研究中，相对亲脂性与活性之间没有明显的相关性。我们的结果表明，呫吨有潜力作为传统抗菌化合物的替代品，也可用于微生物污染水体的净化。
