Wainwright M
Department of Chemistry, University of Central Lancashire, Preston, UK.
J Antimicrob Chemother. 1998 Jul;42(1):13-28. doi: 10.1093/jac/42.1.13.
Whereas the photodynamic therapy (PDT) of cancer has recently shown rapid clinical acceptance, photodynamic antimicrobial chemotherapy (PACT)--which predates the related cancer regimen--is not widely appreciated. Like PDT, PACT utilizes photosensitizers and visible or ultraviolet light in order to give a phototoxic response, normally via oxidative damage. Currently, the major use of PACT is in the disinfection of blood products, particularly for viral inactivation, although more clinically-based protocols are being developed, e.g. in the treatment of oral infection. The technique has been shown to be effective in vitro against bacteria (including drug-resistant strains), yeasts, viruses and parasites. A wide range of photosensitizers, both natural and synthetic, is available with differing physicochemical make-up and light-absorption properties. PACT is proposed as a potential, low-cost approach to the treatment of locally occurring infection.
虽然癌症的光动力疗法（PDT）最近已迅速获得临床认可，但早于相关癌症疗法的光动力抗菌化疗（PACT）却未得到广泛重视。与PDT一样，PACT利用光敏剂和可见光或紫外线以产生光毒性反应，通常是通过氧化损伤。目前，PACT的主要用途是血液制品消毒，特别是用于病毒灭活，不过更多基于临床的方案正在研发中，例如用于口腔感染的治疗。该技术已被证明在体外对细菌（包括耐药菌株）、酵母、病毒和寄生虫有效。有多种天然和合成的光敏剂可供选择，它们具有不同的物理化学组成和光吸收特性。PACT被认为是一种治疗局部感染的潜在低成本方法。
