Baggiolini M, Clark-Lewis I
Theodor-Kocher Institute, University of Bern, Switzerland.
FEBS Lett. 1992 Jul 27;307(1):97-101. doi: 10.1016/0014-5793(92)80909-z.
Interleukin-8 (IL-8) belongs to a family of small, structurally related cytokines similar to platelet factor 4. It is produced by phagocytes and mesenchymal cells exposed to inflammatory stimuli (e.g., interleukin-1 or tumor necrosis factor) and activates neutrophils inducing chemotaxis, exocytosis and the respiratory burst. In vivo, IL-8 elicits a massive neutrophil accumulation at the site of injection. Five neutrophil-activating cytokines similar to IL-8 in structure and function have been identified recently. IL-8 and the related cytokines are produced in several tissues upon infection, inflammation, ischemia, trauma etc., and are thought to be the main cause of local neutrophil accumulation.
白细胞介素-8（IL-8）属于一类结构相关的小分子细胞因子家族，与血小板因子4相似。它由暴露于炎症刺激（如白细胞介素-1或肿瘤坏死因子）的吞噬细胞和间充质细胞产生，并激活中性粒细胞，诱导趋化性、胞吐作用和呼吸爆发。在体内，IL-8在注射部位引发大量中性粒细胞聚集。最近已鉴定出五种在结构和功能上与IL-8相似的中性粒细胞激活细胞因子。IL-8及相关细胞因子在感染、炎症、缺血、创伤等情况下在多种组织中产生，被认为是局部中性粒细胞聚集的主要原因。
