呼出一氧化氮、肺功能测定与哮喘症状的相关性

Correlation of exhaled nitric oxide, spirometry and asthma symptoms.

作者信息

Spergel Jonathan M, Fogg Matthew I, Bokszczanin-Knosala Aleksandra

机构信息

Allergy Section, Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

出版信息

J Asthma. 2005 Dec;42(10):879-83. doi: 10.1080/02770900500371344.

DOI:10.1080/02770900500371344

PMID:16393728

Abstract

Asthma is the most common chronic disease of childhood. Asthma severity is monitored by spirometry. However, this does not directly measure airway inflammation. Exhaled nitric oxide (FeNO) is a proposed method to measure airway inflammation non-invasively. Previous studies have shown that FeNO correlates with endobronchial biopsies and symptoms in patients with asthma. We monitored daily asthma symptoms compared to monthly spirometry and FeNO. Total monthly symptom scores correlated with both forced expiratory volume at 1 sec (FEV1) and FeNO. FeNO had a strong correlation than FEV1. FeNO and FEV1 were not correlated. We propose that FeNO should be used as an additional monitoring tool for asthma.

摘要

哮喘是儿童期最常见的慢性疾病。哮喘严重程度通过肺功能测定来监测。然而，这并不能直接测量气道炎症。呼出一氧化氮（FeNO）是一种用于无创测量气道炎症的方法。既往研究表明，FeNO与哮喘患者的支气管活检及症状相关。我们将每日哮喘症状与每月的肺功能测定和FeNO进行了比较。每月总症状评分与第1秒用力呼气量（FEV1）和FeNO均相关。FeNO的相关性比FEV1更强。FeNO与FEV1不相关。我们建议将FeNO用作哮喘的一种额外监测工具。