Larter Raima, Craig Melissa Glendening
Department of Chemistry, Indiana University--Purdue University at Indianapolis (IUPUI), Indianapolis, Indiana 46202, USA.
Chaos. 2005 Dec;15(4):047511. doi: 10.1063/1.2102467.
Here we present a new model for the generation of complex calcium-bursting patterns in astrocytes, a type of brain cell recently implicated in a variety of neural functions including memory formation. The model involves two positive feedback processes, in which the key feedback species are calcium ion and glutamate. The latter is the most abundant excitatory neurotransmitter in the brain and has been shown to be involved in bidirectional communication between astrocytes and nearby neurons. The glutamate feedback process considered here is shown to be critical for the generation of complex bursting oscillations in the astrocytes and to, perhaps, code for information which may be passed from neuron to neuron via the astrocyte. These processes may be involved in memory storage and formation as well as in mechanisms which lead to dynamical diseases such as epilepsy.
在此，我们提出了一种新模型，用于生成星形胶质细胞中复杂的钙脉冲模式。星形胶质细胞是一种最近被认为参与包括记忆形成在内的多种神经功能的脑细胞类型。该模型涉及两个正反馈过程，其中关键的反馈物质是钙离子和谷氨酸。后者是大脑中最丰富的兴奋性神经递质，并且已被证明参与星形胶质细胞与附近神经元之间的双向通信。这里所考虑的谷氨酸反馈过程对于星形胶质细胞中复杂爆发振荡的产生至关重要，并且可能对经由星形胶质细胞从一个神经元传递到另一个神经元的信息进行编码。这些过程可能参与记忆存储和形成，以及导致癫痫等动态疾病的机制。
