溴化乙锭抑制禽肉瘤病毒感染的鸭细胞中闭合环状病毒DNA的出现以及病毒特异性DNA的整合。
Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus.
作者信息
Guntaka R V, Mahy B W, Bishop J M, Varmus H E
出版信息
Nature. 1975 Feb 13;253(5492):507-11. doi: 10.1038/253507a0.
DOI:10.1038/253507a0
PMID:163973
Abstract
The DNA of avian sarcoma virus assumes a closed circular configuration before integration into the host cell chromosomal DNA. Ethidium bromide reduces the formation of superhelical viral DNA and concurrently blocks integration of the viral genome. Inhibition of integration of viral DNA results in the inhibition of virus replication.
摘要
禽肉瘤病毒的DNA在整合到宿主细胞染色体DNA之前呈闭环结构。溴化乙锭会减少超螺旋病毒DNA的形成，同时阻止病毒基因组的整合。病毒DNA整合的抑制会导致病毒复制的抑制。
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