Benzenhöfer U, Passie T
Senckenbergisches Institut für Geschichte der Medizin, Universität Frankfurt am Main.
Nervenarzt. 2006 Jan;77(1):95-6, 98-9. doi: 10.1007/s00115-005-2001-y.
There is no consensus in the literature regarding the early history of MDMA (Methylendioxymethamphetamine, so-called "Ecstasy"). Various authors credit the first synthesis of MDMA to the German chemist Fritz Haber, but it appears neither in his doctoral thesis (Berlin 1891) nor in his accompanying articles. The man who first synthesized MDMA was the chemist Dr. Anton Köllisch, who worked for the German pharmaceutical company Merck. He created MDMA as a by-product while trying to synthesize hydrastinin, a styptic substance. In 1912, Merck filed to patent the applied method of preparation. The patent was issued in 1914, yet no pharmaceutical testing followed at that time.
关于摇头丸（3,4－亚甲基二氧甲基苯丙胺，即所谓的“摇头丸”）的早期历史，文献中尚无定论。不同的作者认为摇头丸的首次合成归功于德国化学家弗里茨·哈伯，但它既未出现在他1891年于柏林发表的博士论文中，也未出现在他的相关文章里。首次合成摇头丸的人是为德国制药公司默克工作的化学家安东·科利施博士。他在尝试合成一种止血物质——白毛茛碱时，将摇头丸作为副产品创造了出来。1912年，默克公司提交了所应用制备方法的专利申请。该专利于1914年获批，但当时并未进行药物测试。
