Wu Shuhui, Jiang Xiaoqing, Zhou Xuhong, Yin Shucheng
Department of Otolaryngology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Oct;19(20):932-5.
To study the expression of BAG-1 and p53 in laryngeal squamous cell carcinoma (LSCC), and the relation between BAG-1 and p53.
BAG-1 and p53 protein were examined by using the method of immunohistochemical SP staining method in 40 cases of LSCC, 27 cases of pap- a-cancerous tissues and 20 cases of polyp specimens from vocal cord tissues.
The positive expression of BAG-1 in. LSCC was significantly higher than that in para-cancerous tissues and polyp specimens from vocal cord tissues (P < 0.05). The positive expressions of BAG-1 were related to the prognosis (P < 0.05), and BAG-1 in LSCC with nucleus staining had worse prognosis than that with cytoplasm staining (P < 0.05). The positive expression of p53 in LSCC was significantly higher than that in para-cancerous tissues and polyp specimens from vocal cord tissues (P < 0.05). The positive expressions of p53 were related to the differentiation grades, cervical lymph node metastasis and prognosis (P < 0.05). There was no significance correlation between BAG-1 and p53 expression (P > 0.05).
Over expression of BAG-1 and p53 play an important role in the process of development of LSCC; BAG-1 may be a biological predictor of early period in LSCC, especially nuclear BAG-1 localization may be a prediction of unfavorable outcome. Expression of p53 is related with cervical lymph node metastasis, and that is a prognostic target.
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