Salifu Moro O, Tedla Fasika, Markell Mariana S
Division of Renal Diseases, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA.
Semin Dial. 2005 Nov-Dec;18(6):520-8. doi: 10.1111/j.1525-139X.2005.00099.x.
Although renal transplantation offers survival and quality of life advantages as a renal replacement therapy, a substantial proportion of transplant recipients develop worsening of preexisting medical diseases or new complications, including sequelae of rejection, new onset diabetes after transplantation (NODAT), hyperlipidemia, opportunistic infections, cancer, and other systemic diseases secondary to immunosuppression. Management of these problems can be a complex endeavor due to medication interactions that often affect immunosuppression levels. However, successful management of the chronic medical problems associated with renal transplantation can prolong the life span of the graft and the patient.
尽管肾移植作为一种肾脏替代疗法,在提高生存率和生活质量方面具有优势,但仍有相当一部分移植受者会出现原有疾病的恶化或新的并发症,包括排斥反应的后遗症、移植后新发糖尿病(NODAT)、高脂血症、机会性感染、癌症以及免疫抑制继发的其他全身性疾病。由于药物相互作用常常影响免疫抑制水平,这些问题的管理可能是一项复杂的工作。然而,成功管理与肾移植相关的慢性疾病问题,可以延长移植物和患者的寿命。