Burgaz S, Rezanko R, Kara S, Karakaya A E
Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
J Clin Pharm Ther. 1992 Jun;17(3):169-72. doi: 10.1111/j.1365-2710.1992.tb01287.x.
Biological monitoring of exposure to ethylene oxide (EO) was carried out in 31 hospital workers in the sterilization facilities of five hospitals. The excretion of total thioethers was determined in the urine of sterilization workers. An occupational nonexposed group served as a control (n = 31). The air EO level was not monitored routinely, however, peak concentrations of EO up to 200 p.p.m. were detected mainly when the sterilization chambers were open. Our results show a significant difference in urinary thioether excretion between the exposed and control groups (P less than 0.001). Sterilization workers seem to absorb significant quantities of EO. We feel that other alternative and more sensitive methods for detecting thioether metabolites of EO should be carried out to confirm our results.
对五家医院消毒设施中的31名医院工作人员进行了环氧乙烷（EO）暴露的生物监测。测定了消毒工作人员尿液中总硫醚的排泄量。以一组未接触职业性暴露的人员作为对照组（n = 31）。虽然未常规监测空气中的环氧乙烷水平，但主要在消毒室打开时检测到环氧乙烷的峰值浓度高达200 ppm。我们的结果显示，暴露组和对照组的尿硫醚排泄量存在显著差异（P < 0.001）。消毒工作人员似乎吸收了大量的环氧乙烷。我们认为应该采用其他更灵敏的方法来检测环氧乙烷的硫醚代谢产物，以证实我们的结果。
